http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108484715-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
filingDate | 2018-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2022-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-108484715-B |
titleOfInvention | A kind of protein-bound nano-selenium and its preparation method and application |
abstract | The invention belongs to the technical field of biomedicine, and discloses a protein-bound nano-selenium and a preparation method and application thereof. The preparation method is to open the internal space structure of a protein or polypeptide containing a disulfide bond under the reduction action of a disulfide bond reducing agent to obtain a sulfhydryl group with reducing activity, and then part of the sulfhydryl group reduces the selenium compound to elemental selenium, and the rest The sulfhydryl groups re-form intramolecular and intermolecular disulfide bonds, and self-assemble into protein-bound nano-selenium; greatly improve the dispersion and stability of nano-elemental selenium in solution. Animal experiments show that this active red elemental selenium has high bioavailability and low acute toxicity. The protein-bound nano-element selenium prepared by the method of the invention can play the dual role of binding protein and nano-selenium, has small nano-particle size and narrow distribution range, can be stored in liquid phase, and is favorable for oral, injection or spray use. |
priorityDate | 2018-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 831.