http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108484687-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbd1b2ec9da9bfeadfe8092cc7d23ea6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0487 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K103-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2018-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_059506444467bac535f91438c3a0305d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8746724b07c486ed929d21ed542e2e21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d77d17a69757f99b793f56ef41e8cdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_540814b6d588e18cb4ae3876be7574ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_988f72b1106dc3e2db0fa9f13256aa63 |
| publicationDate | 2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108484687-A |
| titleOfInvention | Preparation method and application of technetium-99m labeled triphenylphosphine salt derivative |
| abstract | The present invention relates to the preparation method and application of technetium-99m-labeled triphenylphosphine salt derivatives, which can effectively solve the problem of preparing triphenylphosphine salt derivatives and being used as cationic myocardial imaging agents. The method is, ω-bromine Reaction of aliphatic acid I to obtain ω-bromo aliphatic acid chloride II, react ω-bromo aliphatic acid chloride II with ferrocene to generate intermediate III in which chlorine is substituted by ferrocene, and intermediate III with triphenyl phosphine reaction, the solid product precursor IV was obtained by separation, and the Na 99m TcO 4 eluent with a radioactivity of 740 MBq was added to a polytetrafluoro high-pressure tank, dried with N 2 , and the product precursor, Cr(CO ) 6 , CrCl 3 and methanol, sealed polytetrafluoro high pressure tank; magnetic stirring under oil bath, then ice bath, filter, the filtrate is purified by HPLC, analyzed and identified to obtain technetium-99m labeled triphenylphosphine salt derivative IV, The method of the invention is simple, easy to operate, rich in raw materials, low in cost and high in yield, is effectively used for preparing SPECT myocardial perfusion imaging agent, and has great medical and commercial value. |
| priorityDate | 2018-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.