http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108484578-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2018-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108484578-B |
| titleOfInvention | A kind of method of esomeprazole impurity preparation |
| abstract | The invention discloses a kind of esomeprazole impurity preparation method, with 2- chloromethyl -4- methoxyl group -3,5- dimethyl pyrazole thiamine hydrochloride be starting material, by demethylation, it is halogenated, condensation and asymmetric oxidation obtain 5- methoxyl group -2- [( S )-[(the chloro- 3,5- dimethyl -2- pyridyl group of 4-) methyl] sulfinyl] -1 H Benzimidazole (II).The synthetic route is brief, and starting material is easy to get, and reaction condition is mild, easy to operate, and not needing column chromatography can be obtained above-mentioned impurity, and prepared impurity purity, which can reach 99% or more, ee value, can reach 99% or more, can be used as reference substance for quality research. |
| priorityDate | 2018-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.