| abstract |
The invention discloses (S)-4-chloro-1-(2,5)-difluorophenylbutan-1-alcohol and its preparation method and application, the (S)-4-chloro-1-(2 ,5)-difluorophenylbutan-1-alcohol has a chemical structure shown in formula I: The present invention utilizes cheap and easy-to-obtain raw material 4-chloro-1-(2,5)-difluorophenylbuta-1-one, and adopts biological enzyme method to synthesize (S)-4-chloro-1-(2,5 )-difluorophenylbuta-1-alcohol, and then utilize (S)-4-chloro-1-(2,5)-difluorophenylbutan-1-alcohol to synthesize the key intermediate of larotrectinib in two or three steps (R)-2-(2,5-difluorophenyl)pyrrolidine has the advantages of high yield, simple operation, low production cost, mild reaction conditions, etc., and has extremely strong practical value for realizing the industrialization of larotrectinib. |