http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108478876-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-102 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-02 |
| filingDate | 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108478876-B |
| titleOfInvention | Vascularization promoting bone tissue engineering scaffold and preparation method and application thereof |
| abstract | The invention provides a preparation method of a vascularization promoting bone tissue engineering scaffold, which comprises the following steps: reacting an aqueous solution containing water-soluble calcium salt, water-soluble copper salt, water-soluble zinc salt and a surfactant with an aqueous solution of phosphate by adopting a chemical precipitation method to prepare calcium-deficient apatite slurry, and drying to obtain powder; wherein the molar ratio of the water-soluble calcium salt to the water-soluble copper salt to the water-soluble zinc salt is 15-168: 1: 1; mixing the obtained powder with the liquid phase solution to prepare slurry, injecting the slurry into a mold, and performing drying molding and high-temperature sintering to obtain a porous calcium phosphate ceramic support; and loading the microspheres carrying GDF-5 on the surface of the obtained porous calcium phosphate ceramic scaffold, and drying in vacuum to obtain the vascularization promoting bone tissue engineering scaffold. The tissue engineering scaffold obtained by the invention has excellent osteoconductivity, osteoinductivity, biodegradability and vascularization promoting performance, solves the problem of rapid repair of bone defect, and has good practical application prospect. |
| priorityDate | 2018-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.