| abstract |
The invention discloses a preparation method of epirubicin hydrochloride and an intermediate thereof. The method comprises the following steps: in an organic solvent, under the action of a base, the compound 4 is subjected to the following esterification reaction with trifluoromethanesulfonic anhydride to obtain the compound 4'. The preparation method of the present invention has the advantages of short route, high yield, easy acquisition of reaction raw materials, no need to use other expensive reagents, low cost, mild reaction conditions, simple operation, and is beneficial to industrial production. |