http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108440627-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4a267ec8606bc54e197aef893286ec7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-167 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-167 |
| filingDate | 2018-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e016d3c8bc5c4dd4c8b4c62709a9775f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc2d88bc8d16084fafaf0bdd3d8c8020 |
| publicationDate | 2018-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108440627-A |
| titleOfInvention | Method for preparing cangrelor key intermediate with diaminomercaptopyrimidine |
| abstract | It involves a method for preparing the key intermediate of cangrelor with diaminomercaptopyrimidine, which uses 4,6-diamino-2-mercaptopyrimidine as the starting material, and first adds trifluoropropyl under alkaline conditions to obtain the intermediate 1, then add an amine group to obtain intermediate 2; then attach 2-[(3,3,3-trifluoropropyl)thio]-9H-purine-6-amine to a glycosidic bond to obtain intermediate 4; The acetyl group is added to obtain intermediate 5; then the upper branch is obtained to obtain intermediate 6; finally, the key intermediate of cangrelor is obtained by hydrolysis and acidification. The product synthesized by this method is a light yellow or yellow solid, which can be determined to be the pure product of the key intermediate of cangrelor through LC-MS and H NMR. The method has the advantages of low cost, high yield, mild reaction conditions, simple post-treatment and great potential for industrialization. |
| priorityDate | 2018-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID465901332 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID164074968 |
Total number of triples: 16.