http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108440577-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108440577-B |
| titleOfInvention | Mixed copper-based complex and preparation method and application thereof |
| abstract | The invention discloses a mixed copper-based complex and a preparation method and application thereof. The structural formula of the mixed copper-based complex is [ Cu (C) 10 H 10 NO 5 SBr)(C 12 H 8 N 2 )]·CH 3 OH, wherein [ Cu (C) 10 H 10 NO 5 SBr)(C 12 H 8 N 2 )]Is a coordination unit, C 10 H 10 NO 5 SBr is a Schiff base anionic ligand, C 12 H 8 N 2 Is a neutral ligand 1,10' -phenanthroline. The preparation method comprises the steps of mixing taurine and strong base, adding an organic solvent, stirring for dissolving, then adding 5-bromo-2-hydroxy-3-methoxybenzaldehyde, stirring for 2-4 hours at a constant temperature, stopping reaction, and obtaining potassium salt K of the ligand 2 C 10 H 10 NO 5 SBr; then the potassium salt K of the ligand 2 C 10 H 10 NO 5 And mixing SBr and copper salt, dissolving in a mixed solvent of methanol/water, adding 1,10' -phenanthroline, reacting at constant temperature for 8-20 h, and obtaining the mixed copper-based complex after the reaction is finished. The mixed copper-based complex is a candidate of an anti-tumor medicament, is a good tumor angiogenesis inhibitor, and is a candidate of a novel bifunctional anti-tumor medicament. |
| priorityDate | 2018-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.