http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108440530-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41e7550911d3e588caa3fbc6a252ad80 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-22 |
| filingDate | 2018-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa27e43980de524242d1c691d798d16e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8937f709707dfde0f96955578ec6c0b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ea0c026633286752116f3ab66c7a13a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4811625daafa642c98adc607643dfde1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b054d1e9cdb52d33d9debe01535eb1cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efb90e69f394c8a1acaa5169cd4193c2 |
| publicationDate | 2018-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108440530-A |
| titleOfInvention | A tetrahydroisoquinolinopyrrole skeleton double-spiro epoxy indole and its preparation method |
| abstract | The invention discloses a tetrahydroisoquinolinopyrrole skeleton double-spiro epoxy indole and a preparation method thereof, belonging to the technical field of organic synthesis. In the present invention, isatin, tetrahydroisoquinoline and 3-ene oxide indole are added to a toluene solvent, trifluoroacetic acid is used as a catalyst, and a three-component [3+2] ring is generated at a temperature of 50 o C. Addition reaction to prepare double spiro indoxindole. The present invention adopts a one-pot cooking method to avoid the separation of intermediates, and after the reaction is complete, the pure product can be obtained through column chromatography or simple filtration. The invention has the advantages of mild reaction conditions, simple operation, wide substrate range and the like. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113004307-A |
| priorityDate | 2018-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.