http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108440330-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 |
| filingDate | 2018-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108440330-B |
| titleOfInvention | Preparation method of doxycycline hydrochloride |
| abstract | The invention provides a preparation method of doxycycline hydrochloride. The preparation method comprises the following steps: carrying out hydrogenation reaction on 11 a-chloro-6-methenyloxytetracycline p-toluenesulfonate under the conditions of a catalyst and a toxic agent; then, the alpha-6-deoxyoxytetracycline sulfosalicylate is obtained by reaction with sulfosalicylic acid; reacting with a hydrogen chloride-ethanol solution, adding water, stirring and crystallizing to obtain doxycycline hydrochloride; wherein said toxic agents comprise: mixtures of sulfur-containing and nitrogen-containing organics. The method can improve the yield and stereoselectivity of doxycycline hydrochloride and obtain high-quality raw material medicines. |
| priorityDate | 2018-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.