| abstract |
The present invention relates to the use of sound waves to manipulate and sort particles and cells. In an embodiment, there is provided a microfluidic device for manipulating particles in a fluid suspension, the device comprising: (a) a substrate; (b) a channel defined in the substrate, the channel having a microfluidic device for receiving the fluid suspension and (c) an acoustic source configured to deliver surface acoustic waves traveling transverse to the flow of the fluid suspension in the channel, wherein the acoustic source is an interdigitated A transducer (IDT) comprising a plurality of concentric circular arcs with a tapered end pointing toward the channel, and the tapered end has a pore size between 4 μm and 150 μm. In an alternative embodiment, the device includes a second channel disposed intermediate the first channel and the sound source, wherein the first and second channels are connected by a pumping channel. |