| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a8d821d05ce6ef1e19615d65d337f24 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7052 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6887
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-581 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 |
| filingDate |
2017-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbdcb1d15ccd9d30aa6f679634313608
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8b4c76f8711926db552cc1807c2d1b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1e019edbbfc6f889f8454f1eab9b32e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c42ec0fc32d3dfa496c0b7bfb5bb15be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de66205a4a09bfbb3c1aa5b022f4f7b8 |
| publicationDate |
2018-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-108431606-A |
| titleOfInvention |
Combined Biomarker Measurements of Fibrosis |
| abstract |
Provided herein is a sandwich immunoassay for the detection of cross-linked PIIINPs having at least two PIIINP chains linked together by interchain crosslinks, each chain having N protease composed of intact type III procollagen C-terminal neo-epitopes of PIIINP generated by cleavage. A biological sample with cross-linked PIIINP is contacted with a first surface-bound monoclonal antibody, followed by a second monoclonal antibody, both of which are specifically reactive with the neo-epitope in the C-terminal sequence of PIIINP, and then Binding of the second monoclonal antibody was determined. Also provided is a method of assessing the efficacy of an antagonist drug targeting lysyl oxidase by an immunoassay and a kit comprising a solid support bound to a first monoclonal antibody and comprising a second monoclonal antibody. |
| priorityDate |
2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |