| abstract |
Disclosed herein are alkylphosphorylcholine analogs incorporating a chelating moiety, wherein the chelating moiety is chelated to gadolinium. Alkylphosphorylcholine analogs are compounds of the formula: or its salt. R 1 comprises a chelating agent chelated to a gadolinium atom, a is 0 or 1, n is an integer of 12-30, m is 0 or 1, and Y is -H, -OH, -COOH, -COOX, -OCOX or - OX, wherein X is alkyl or arylalkyl, R 2 is -N + H 3 , -N + H 2 Z, -N + HZ 2 or -N + Z 3 , wherein each Z is independently alkyl or aralkyl, b is 1 or 2. The compounds can be used to detect or treat solid tumors. In detection/imaging applications, gadolinium emits signals that can be detected with magnetic resonance imaging. In medicine, gadolinium emits tumor-targeted charged particles when exposed to epithermal neutrons. |