| abstract |
Compositions and methods are described for inducing an immune response against extraintestinal pathogenic Escherichia coli (ExPEC), thereby providing immune protection against diseases associated with ExPEC. In particular, compositions and methods are described regarding the use of conjugates of E. coli polysaccharide antigens O25B, O1A, O2 and O6A covalently bound to the detoxified exotoxin A of the Pseudomonas aeruginosa (EPA) carrier protein as vaccines, For the prevention of aggressive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B. |