http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108424382-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108424382-B |
| titleOfInvention | 3,3' -disubstituted bipyridine derivative and preparation method and application thereof |
| abstract | The invention discloses a 3,3 '-disubstituted bipyridine derivative, a preparation method thereof and application thereof in preparing anti-Alzheimer's disease drugs. The chemical formula of the 3,3' -disubstituted bipyridine derivative is shown as a formula I and a formula II. Wherein R is-H, halogen, -O (CH) 2 )mCH 3 Amino substituted with 1 or more methyl or ethyl groups; r 1 is-O (CH) 2 )mCH 3 ，‑OH；R 2 An aliphatic hydrocarbon of C1 to C5, an amino group substituted with 1 or more methyl groups or ethyl groups, ， . The invention also discloses a preparation method and application of the derivative. The 3,3' -disubstituted bipyridine derivative has the functions of inhibiting A beta aggregation, metal complexing ability and inhibiting metal ion-induced A beta aggregation activityHas low toxicity and high safety. Therefore, the 3,3' -disubstituted bipyridine derivative has wide application space in preparing the anti-Alzheimer disease medicine. |
| priorityDate | 2018-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.