http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108409663-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108409663-B |
| titleOfInvention | Microtubule inhibitors, methods of preparation and uses thereof |
| abstract | The invention relates to a microtubule inhibitor, a preparation method and application thereof, belonging to the field of chemical drugs. The invention aims to solve the problem that the cis conformation of the existing microtubule inhibitor CA-4 is easily converted into the trans conformation, so that the biological activity is rapidly reduced. The experimental result shows that the compound can be used for tumor cells such as ovarian cancer cells, cervical cancer cells, non-small cell lung cancer cells, colon cancer cells, breast cancer cells and the likeStrong in vitro antiproliferative activity, can obviously inhibit the tumor development in vivo, and has good safety. |
| priorityDate | 2018-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 151.