| abstract |
The present application relates to hydroxylamine-substituted Michaelis acid, barbituric acid and pyrazolone derivatives as HNO donors. The presently disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising the compounds, and methods of using the compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using the compounds or pharmaceutical compositions to treat, prevent or delay the onset and/or progression of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular disease, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension, and conditions responsive to nitroxyl therapy. |