http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108409618-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-36 |
| filingDate | 2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108409618-B |
| titleOfInvention | A kind of method of light/nickel concerted catalysis synthesis 3- methylthio diphenylamine |
| abstract | The invention discloses a kind of light/nickel concerted catalysis synthesis 3- methylthio diphenylamine methods, this method is using cheap 3- methyl mercapto aniline and halogeno-benzene as raw material, light/nickel concerted catalysis strategy is applied to building C-N key for the first time, synthesizes pyridazine class key intermediate of medicament 3- methylthio diphenylamine.The advantage of this method is that: 1) photochemical catalyst dosage low, is the 0.01%~0.02% of halogeno-benzene mole；2) directly using nickel salt as metallic catalyst, such as nickelous bromide is not necessarily to additional ligand；3) reaction condition is mild, can effectively carry out at 40~50 DEG C；4) product is directly obtained through vacuum distillation, can be easily separated.These significant advantages make the present invention have good prospects for commercial application. |
| priorityDate | 2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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