http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108403643-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate | 2018-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108403643-B |
| titleOfInvention | Long-acting microsphere of protein polypeptide drug and preparation method thereof |
| abstract | The invention relates to a long-acting microsphere of a protein polypeptide drug and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving protein or polypeptide water-soluble medicine and protein protectant in water to obtain water-phase medicine solution; dissolving a high molecular carrier material in an organic solvent to obtain an oil-phase high molecular solution; (2) adding the water-phase drug solution into the oil-phase polymer solution, and preparing into W/O emulsion by using a cell disruptor or a high-speed shearing instrument; (3) and (3) feeding the W/O emulsion into an ultrafine particle preparation system at a constant speed through a peristaltic pump to prepare the long-acting protein polypeptide drug microspheres. The preparation method has the advantages of simple prescription, mild conditions, simple preparation process, controllable parameters, good reproducibility and high production efficiency. The protein polypeptide drug microsphere prepared by the method has the advantages of high drug encapsulation rate, low burst release rate, stable and durable drug release rate, smooth surface, complete spherical shape and uniform particle size. |
| priorityDate | 2018-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.