http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108395479-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28 |
| filingDate | 2017-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108395479-B |
| titleOfInvention | A T-cell receptor implicated in KRAS gene mutation |
| abstract | The invention discloses a T cell receptor, which specifically binds to the KRAS gene 12 codon mutation G12D 26aa peptide segment, the amino acid sequence of the peptide segment is: MTEYKLVVVGADGVGKSALTIQLIQN, as shown in SEQ ID NO: 1; the T cell When the receptor has a 9-12aa antigenic epitope polypeptide with a higher affinity for recognizing the HLA molecule antigen complex, the polypeptides are as follows: VVVGADGVGK, as shown in SEQ ID NO: 48; KLVVVGADGVGK, as shown in SEQ ID NO: 49; the The HLA molecule is HLA-A0301; when recognizing the antigen complex formed by the KRAS gene G12D mutant peptide and HLA-A0301, the amino acid sequences of the α chain and the β chain of the T cell receptor are disclosed. In addition, the present invention also discloses the nucleotide sequence encoding the α chain and the β chain of the above-mentioned T cell receptor, a vector comprising the above-mentioned nucleotide sequence, a cell comprising the above-mentioned nucleotide sequence, and the preparation of the above-mentioned vector or the above-mentioned cell. Application of medicines for preventing and treating KRAS gene mutation-related diseases. |
| priorityDate | 2017-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.