abstract |
The present invention relates to a chimeric antigen receptor targeting BCMA(J22.9)-tEGFR-aPD1 and its use. Specifically, the present invention provides a polynucleotide sequence selected from: (1) coding sequence of anti-BCMA single chain antibody, coding sequence of human CD8α hinge region, coding sequence of human CD8 transmembrane region, The coding sequence of human 41BB intracellular region and human tEGFR and the coding sequence of anti-human PD1 single-chain antibody; and (2) the complementary sequence of the polynucleotide sequence of (1). The present invention also provides related fusion proteins, vectors containing the coding sequences, and uses of the fusion proteins, coding sequences, and vectors. |