http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108395460-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 |
| filingDate | 2018-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108395460-B |
| titleOfInvention | Hypoxia activated adriamycin prodrug and preparation method thereof |
| abstract | The invention discloses a hypoxia activated adriamycin prodrug and a preparation method thereof, wherein an azo bond with hypoxia activation effect and a response functional group of a self-occlusion structure are modified on the amino group at the 3' position of adriamycin to synthesize the adriamycin prodrug, the drug can effectively realize selective activation in a hypoxia environment, and can realize the regulation and control of the growth activity of tumor cells by regulating the distribution of subcellular organelles of the adriamycin in a normoxic and hypoxic environment, so that the toxic and side effects of the drug on normal cells are reduced, the targeting efficiency of tumor treatment is improved, and more new ideas are provided for the development of antitumor drugs. The hypoxic activated adriamycin prodrug provided by the invention has the advantages of simple synthesis method, cheap and easily available raw materials, and easiness in industrial production and clinical transformation. |
| priorityDate | 2018-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.