http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108395428-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 |
| filingDate | 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108395428-B |
| titleOfInvention | Benzothiazole-triazole-isatin type compound and synthesis and application thereof |
| abstract | The invention discloses a benzothiazole-triazole-isatin type compound and synthesis and application thereof, wherein the preparation method comprises the following steps: preparing 1- (benzo [ d ] thiazole-2-yl) ethan-1-ol by placing 2-aminothiophenol and lactic acid, and then placing the 1- (benzo [ d ] thiazole-2-yl) ethan-1-ol and chromium trioxide into a round-bottom flask to prepare 1- (benzo [ d ] thiazole-2-yl) ethan-1-one; then putting the mixture, N-bromosuccinimide and p-toluenesulfonic acid into a round-bottom flask, and adding acetonitrile to prepare 1- (benzo [ d ] thiazole-2-yl) -2-bromoethyl-1-ketone; then putting the compound and sodium azide in a round-bottom flask, adding tetrahydrofuran to prepare a product, putting the product, substituted 1- (prop-2-yne-1-yl) indoline-2, 3-diketone, sodium vitamin C and copper sulfate pentahydrate in the round-bottom flask, and adding DMF to obtain the benzothiazole-triazole-isatin type compound. The preparation method disclosed by the invention is simple in steps and convenient to operate, and the prepared benzothiazole-triazole-isatin compound has good inhibitory activity on alpha-glucosidase, so that a new choice is provided for development and application of antidiabetic drugs. |
| priorityDate | 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.