http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108392636-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 |
| filingDate | 2018-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108392636-B |
| titleOfInvention | A preparation method of graphene drug carrier with folic acid and WGA as targeting factors |
| abstract | The invention relates to a graphene with dual targeting factors of folic acid and wheat germ agglutinin prepared from graphene oxide, 6-carboxymethyl-γ-cyclodextrin, folic acid and wheat germ agglutinin (WGA) as main raw materials Nano drug carrier and its preparation method. The present invention first uses graphene oxide and p-toluenesulfonyl chloride as raw materials to activate graphene oxide hydroxyl, graft L-lysine, and use hydrazine hydrate to reduce the graphene oxide grafted with lysine; ‑Ethyl‑(3‑dimethylaminopropyl) carbodiimide (EDC) and N‑hydroxysuccinimide (NHS) under the co-catalysis of 6‑carboxymethyl‑γ‑cyclodextrin and Folic acid reacts to generate nano-graphene grafted with γ-CD and folic acid at the same time, and then assembles wheat germ agglutinin and γ-CD to prepare graphene nano-drug carrier with dual targeting factors of folic acid and wheat germ agglutinin. |
| priorityDate | 2018-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.