http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108383806-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 |
| filingDate | 2018-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108383806-B |
| titleOfInvention | Preparation method of dimeric fluorostatins antibiotics |
| abstract | The invention discloses a preparation method of dimeric fluorostatins antibiotics. Acyl fluostatins are used as raw materials and react overnight in water or methanol and other proton solvents, the acyl fluostatins form a p-quinone ketone methide intermediate through non-enzymatic deacylation, then a C-C/C-N coupled dimeric fluostatins crude product is obtained through 1, 6-nucleophilic addition, and the high-purity dimeric fluostatins antibiotics are obtained through semi-preparative high performance liquid chromatography separation and purification. The preparation method has the characteristics of no need of a catalyst for dimerization reaction, normal temperature and pressure, relatively short time, simple operation, high product yield, stable quality and low cost, and is an effective way for preparing high-purity dimeric fluorostatins. |
| priorityDate | 2018-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.