http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108380236-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J27-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-75 |
| filingDate | 2018-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108380236-B |
| titleOfInvention | Clean production method of drug dapipropamid intermediate for cardiovascular |
| abstract | The invention belongs to the technical field of research and development of new medicines, and particularly relates to a clean production method of a dapipropamid intermediate serving as a cardiovascular medicine. The method comprises the steps of taking zirconium nitride nanoparticles as a carrier, grafting sulfydryl on the surface of the zirconium nitride nanoparticles by using mercaptopropyl trimethoxy silane, and oxidizing to obtain sulfonated zirconium nitride nanoparticles; the sulfonated zirconium nitride nano-particles prepared by the invention can be used for catalyzing esterification reaction of the cyclohexyl formic acid and methanol to prepare a drug Dacetrapib intermediate methyl cyclohexyl formate for cardiovascular use. The catalytic process is green and pollution-free, and the yield of the target product is high. |
| priorityDate | 2018-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.