abstract |
The invention relates to the fields of biotechnology and medicine, and specifically discloses the application of PRAK as a drug target in screening drugs for inhibiting or preventing tumor cell metastasis. Based on the discovery of PRAK as a tumor cell metastasis target, the present invention further provides a drug that can inhibit or prevent tumor cell metastasis. The active ingredients of the drug can reduce the expression level of PRAK or inhibit the biological activity of PRAK, and can regulate cell migration, HIF1α, The expression and/or function of MMP2 and/or EMT series molecules can inhibit or prevent tumor cell metastasis. |