http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108371661-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2018-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108371661-B |
| titleOfInvention | Thiolutin is inhibiting the application in the activation of NLRP3 inflammation corpusculum |
| abstract | The present invention relates to biology and field of medicaments, disclose thiolutin and are inhibiting the application in the activation of NLRP3 inflammation corpusculum.The inventors found that, thiolutin can inhibit activation of the agonist of the different attributes such as ATP, Ni Niya rhzomorph (Nigericin), monosodium urate salt (MSU) to NLRP3 inflammation corpusculum, but the activation for the inflammation corpusculum such as do not influence NLRC4, AIM2；Inhibit the assembling of NLRP3 inflammation corpusculum, including NLRP3 is in conjunction with ASC and ASC spot formation；Inhibit the deubiquitination of NLRP3 albumen；Meanwhile thiolutin can also inhibit the peritonitis of monosodium urate Salt treatment and the septicemia of lipopolysaccharides (LPS) induction；Therefore it can be used as prevention and/or treat the potential drug of NLRP3 inflammation corpusculum abnormal activation related disease. |
| priorityDate | 2018-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 215.