http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108368051-A

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filingDate 2016-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7b103e9cca48f4b6ee41b940b85d045
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publicationDate 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108368051-A
titleOfInvention Trifunctional crosslinking reagents
abstract The present invention relates to trifunctional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) a hydrazone group , for capturing oxidized acceptor-glycoprotein and (iii) an affinity group selected from azido and alkynyl for detecting, isolating and purifying the captured glycoprotein; and its preparation. The invention further provides improved methods of detecting, identifying and characterizing the interactions between ligands and their corresponding target glycoproteins on living cells and in biological fluids. The present invention further provides novel uses of the catalysts in these processes.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110873772-A
priorityDate 2015-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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