http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108362807-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-74 |
| filingDate | 2018-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108362807-B |
| titleOfInvention | Hemodialysis liquid detection method and application thereof in pharmacokinetics-pharmacodynamics of pulse-activating injection |
| abstract | The invention relates to the technical field of medicines, in particular to a hemodialysis liquid detection method and application thereof in hemodynamics-pharmacodynamics of a pulse-activating injection. The invention adopts the awake rat in-vivo microdialysis technology, overcomes the influence of animal anesthesia and blood volume loss on pharmacokinetics and pharmacodynamics behaviors, is successfully applied to the research of relationship between blood concentration-time and drug effect-time of pulse-activating injection for resisting myocardial ischemia of rats, and establishes a pharmacokinetic-pharmacodynamics combined model. The research of the invention shows that when a proper blood endogenous biomarker is selected as a pharmacodynamic index, the in-vivo microdialysis sampling technology of the conscious animal becomes an ideal tool for pharmacokinetics-pharmacodynamics combined research. |
| priorityDate | 2018-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.