http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108358869-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27396494dbf2775fd87cdd0287df497f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-82 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 |
| filingDate | 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4534124a90bab5590609e653a4a37dc6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e601f5c5a871976e6487b7a4bd7001cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d24737d565e64b45f73c0508d3c2570 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea4671a6706bba5f00864d819c233724 |
| publicationDate | 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108358869-A |
| titleOfInvention | A kind of N-benzothiazolylbenzenesulfonamide derivatives, preparation method and application |
| abstract | The invention discloses an N-benzothiazolylbenzenesulfonamide derivative, a preparation method and an application. It is known that scavenger receptor type I of group B (SR‑BI) plays a key role in the reverse cholesterol transport of HDL, thereby reducing the level of cholesterol in plasma, inhibiting the oxidation of LDL and reducing the vascular damage caused by oxidized LDL. . The present invention provides a series of N-benzothiazolylbenzenesulfonamide derivatives that can up-regulate the expression of SR-BI . , -H, -Cl or -NO 2 , the substitution position of the substituent R 1 on the A ring is 3, 4, 5 or 6; the substituent NHR 2 is the ortho, meta or para substitution on the B ring. The prior art has not disclosed the chemical structure, preparation method and pharmacological activity of the N-benzothiazolylbenzenesulfonamide derivatives of the present invention. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113121467-A |
| priorityDate | 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.