http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108358866-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_494c3c23d2752174d704566a459ce444 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-56 |
| filingDate | 2018-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ffeee59dfd3a6865c686a6d60b4770f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63975c459efbcc5e96dcf420552ede3a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4132b5f76e2cbcf7fa0ec1af7a613e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f00d6104edb19a3b2fbf9341b48a61b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a376ef5a518864990558b4aa1b3580cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d812dba2962d38ed2b86502429210b8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b19f284001f4d737055b4c66676e14b3 |
| publicationDate | 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108358866-A |
| titleOfInvention | A kind of preparation method of febuxostat intermediate and its application in preparing febuxostat |
| abstract | The invention provides a preparation method of a compound of structural formula II, comprising the following steps: 1) reacting a compound of structural formula VII under the action of an alkylating agent and a base to obtain a compound of structural formula VI; 2) reacting a compound of structural formula VI obtain the compound of structural formula V; 3) without solvent, the compound of structural formula V reacts with urotropine under acidic conditions to obtain the compound of structural formula IV; 4) the compound of structural formula IV reacts with hydroxylamine hydrochloride in the presence of alkali, dehydration A compound of structural formula III is obtained; 5) a compound of structural formula III and a compound of structural formula VIII are subjected to a ring-closing reaction to obtain a compound of structural formula II. The present invention also provides the application of the above preparation method in the synthesis of febuxostat. The method of the invention has the advantages of simple operation, high yield, less side reactions and no use of severe drugs, and is suitable for industrial production as a novel preparation method of febuxostat intermediate. Wherein, R=C 1 -C 4 alkyl group. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109503512-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109503512-B |
| priorityDate | 2017-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.