http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108358853-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d94573ab2c57e8b193f3a22accddf9fe |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2018-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8d18b5c486fd87817ac170136672460 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d849ab7bdda10dced6c368901199506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5872effcece62f1cc351ac56162de6c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47e48df18e31cbaa193f58b9619e426c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95735f7fbf344308cfc3583aa7a6ceb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e67308068a993c1cfb76722db232dd5d |
| publicationDate | 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108358853-A |
| titleOfInvention | A kind of stilbene analogue against neuroinflammation and its preparation method and application |
| abstract | The invention provides a stilbene analogue against neuroinflammation, its preparation method and application. The structure of the anti-neuroinflammatory stilbene analogue is as follows; wherein, R1 is H, halogen, C1~C5 saturated linear alkyl, C1~C3 substituted by one or more halogen atoms Saturated straight chain alkyl; R 2 is H, O(CH 2 ) m CH 3 , halogen, hydroxyl, C1~C5 saturated straight chain alkyl, C1~C3 saturated straight chain alkyl substituted by 1 or more halogen atoms base. The method for discovering lead compounds based on molecular assembly of the present invention designs new skeleton molecules by assembling pyrimidine piperazine and stilbene fragments, and synthesizes a series of stilbene analogs. The compound provided by the invention has significant anti-neurinflammation activity, can pass through the blood-brain barrier, and can be used as a lead compound for treating senile dementia. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110496117-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110496117-A |
| priorityDate | 2018-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.