http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108358817-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80ea18bbd5908f25ae85ef48d107372a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 |
| filingDate | 2018-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c5ad853036bcf1e67cacbce7d16b548 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cfa968ec9a16c2503775883f0141c89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e23d677d3fb8a0f69637d4b4ff70fed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b44ea6d0cb306aa7b0a36734fc6cb35e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8daa6af52d4dd69660c45aeb70c88ce |
| publicationDate | 2018-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108358817-A |
| titleOfInvention | A kind of preparation method of pimavanserin intermediate and pimavanserin |
| abstract | The invention discloses a pimavanserin intermediate and a preparation method of pimavanserin, the general structural formula of the pimavanserin intermediate is It is obtained by reductive amination of 4-isobutoxybenzaldehyde and carbamate, and its synthetic route is The pimavanserin is obtained by aminolysis. In the preparation method of the pimavanserin intermediate of the present invention, the target intermediate can be obtained in one step through reductive amination reaction, which greatly simplifies the reaction steps of pimavanserin; the raw materials used are safe and the cost is low; the reaction conditions are mild , avoiding the use of phosgene which is highly toxic and difficult to operate, and is easy to realize industrially; the separation and purification of intermediates and products is easy, and even without separating intermediates, the next step reaction can be directly carried out to prepare pimavanserin, and the operation The method is simple, the yield is higher than that of the prior art, and the synthesis cost of pimavanserin is reduced. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110894186-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110894186-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111320569-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111320569-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020234383-A1 |
| priorityDate | 2018-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.