http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108358796-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C221-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 |
| filingDate | 2018-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108358796-B |
| titleOfInvention | Preparation method of lorcaserin key intermediate I |
| abstract | The invention discloses a preparation method of a key intermediate I of lorcaserin, which comprises the following steps: (1) in an organic solvent A, 2,4' -dichloroacetophenone is subjected to condensation reaction with isopropanolamine under the catalysis of alkali to obtain 1- (4-chlorphenyl) -2- ((2-hydroxypropyl) amino) ethane-1-ketone; (2) and (2) carrying out catalytic reduction on the 1- (4-chlorphenyl) -2- ((2-hydroxypropyl) amino) ethane-1-ketone obtained in the step (1) in a solvent B by using sodium borohydride and acid to obtain the key intermediate I of the lorcaserin. The preparation method provided by the invention can realize the purpose of synthesizing the key intermediate I of the lorcaserin under mild reaction conditions by using cheap and easily available raw materials, has the advantages of simple operation, low cost and high yield, is energy-saving and environment-friendly, and is suitable for large-scale production. |
| priorityDate | 2018-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.