| abstract |
The invention discloses application of the metal compound/palladium compound catalytic reduction system in debenzylation containing benzyl compounds and deuterated reaction, reaction includes the following steps：Under nitrogen protection; palladium compound and metal compound are suspended in solvent and stirred 5 minutes; it is added and contains benzyl compounds; it is reacted 0.5~48 hour at 30 DEG C~150 DEG C; ice water stopped reaction is added; pH value is adjusted to 3.5 with dilute hydrochloric acid, and reaction solution passes through solvent extraction, is evaporated, column chromatography purifying, completes reaction. |