http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108355141-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1774 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 |
| filingDate | 2018-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108355141-B |
| titleOfInvention | A kind of drug and preparation method thereof of the treatment allergic disease based on TIM-4-Fc fusion protein |
| abstract | The present invention " a kind of drug and preparation method thereof of the treatment allergic disease based on TIM-4-Fc fusion protein ", belongs to biomedicine field.The active constituent of the drug includes: the TIM-4-Fc fusion protein；And/or the expression vector of the TIM-4-Fc fusion protein can be expressed；And/or the transformant comprising the expression vector；The TIM-4-Fc fusion protein sequence includes TIM-4 protein sequence and IgG protein sequence.Present invention demonstrates that the drug has the function of inhibition and/or asthma occurrence and development, and this inhibiting effect with its be capable of modulating T cell activation and T cell subgroup it is related, and confirm that drug of the invention mainly passes through TIM-4 signal pathway modulating T cell subgroup immune imbalance by mouse experiment in vivo, so as to improve with mitigate asthma symptoms, drug of the invention provides new drug candidate action target spot and new drug selection for clinical treatment asthma, has a good application prospect. |
| priorityDate | 2018-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 448.