http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108351303-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-7786 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-7709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-773 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6441 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2201-0221 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-552 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-7703 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54373 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-77 |
| filingDate | 2016-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108351303-B |
| titleOfInvention | Hollow Polymer Optical Fiber System for Single and Multiplexed Analyte Detection |
| abstract | Provided herein is a near-homogeneous analysis ("alpha") technique based on amplified luminescence, but using dyes doped with 'acceptor beads' (eg, thiane, anthracene, rubrene, and/or lanthanides) chelating agent) or a 'donor bead' dye (eg phthalocyanine) hollow polymer optical fiber carrying the signal generated by the dopant through a singlet oxygen channel for single analyte detection or multiplexed analyte detection method, system and device. In one embodiment, the hollow polymer fiber (106) is doped with an 'acceptor bead' dye. A first binding partner (108) that binds to the analyte of interest (110) binds to the inner surface of the optical fiber. A sample solution, possibly containing the analyte and beads (114), are introduced into the interior of the optical fiber, the beads are embedded with a 'donor bead' dye and have immobilized on their surface also bound to the A second binding partner for the analyte (112). The analyte binds to the donor bead and the optical fiber, thereby bringing the 'donor bead' dye adjacent to the 'acceptor bead' dye. When irradiated with excitation light (102), singlet oxygen is generated in the 'donor bead' dye and channeled to the 'acceptor bead' dye, where the 'acceptor bead' dye , which ultimately causes fluorescence (104) emission, the intensity of which varies with the concentration of the analyte. |
| priorityDate | 2015-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.