http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108350094-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-737 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-737 |
| filingDate | 2016-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108350094-B |
| titleOfInvention | Improved process for producing high purity sulfated HA |
| abstract | The present invention relates to an improved process for the production of sulfated Hyaluronic Acid (HA), sulfated HA-derivatives and/or mixtures thereof, of high purity and with a sulfation degree ranging from 1 to 3, comprising the following steps: dissolving HA-Na or HA-derivative-Na in an aprotic solvent in the presence of an organic sulfonic acid; b) sulfating the obtained solution by adding an excess of a sulfating agent; c) precipitating in ethanol until a precipitate is obtained; d) dissolving the obtained precipitate in a mixture of water and the aprotic solvent used in step a) in the presence of an excess of NaCl, adjusting the pH to a range of 3-4; e) further precipitating with ethanol until a powder is obtained; f) washing the powder from step e) and drying the product thus obtained under vacuum. The invention also relates to the sulfated HA, sulfated HA derivatives and/or mixtures thereof thus prepared, with high purity and with a sulfation degree ranging from 1 to 3, and to the relative pharmaceutical mixtures. |
| priorityDate | 2015-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 77.