| abstract |
Disclosed are isolated or purified T cell receptors (TCRs) that are antigenically specific for the mutated Kirsten rat sarcoma virus oncogene homolog (KRAS) presented in the context of the HLA-Cw*0802 molecule. Also provided are related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, cell populations and pharmaceutical compositions. Also disclosed are methods of detecting the presence of cancer in a mammal, and methods of treating or preventing cancer in a mammal. |