| abstract |
The present invention provides bifunctional proteins prepared by linking biologically active proteins and FGF muteins to the Fc region of immunoglobulins with improved pharmacological potency, in vivo duration and protein stability. The bifunctional protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition containing the bifunctional protein as an active ingredient can be effectively used for diabetes, obesity, dyslipidemia, Therapeutic agent for metabolic syndrome, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis or cardiovascular disease. |