| abstract |
The present invention provides a substituted steroid compound and its application. Specifically, the substituted steroid compound of the present invention is a steroid compound represented by formula (I), or its crystal form, pharmaceutically acceptable salt, prodrug, stereoisomer, hydrate or solvent compound. The substituted steroid compound disclosed in the present invention and the composition comprising the compound have excellent inhibitory activity to CYP17 enzyme and androgen receptor (AR), and at the same time have better properties of pharmacokinetic parameters, and can improve the compound's performance in drug concentration in animals to improve drug efficacy and safety. |