http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108342190-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1029 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6486 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108342190-B |
| titleOfInvention | Nano fluorescent probe for detecting HNO in ratio mode and preparation method and application thereof |
| abstract | The invention relates to a preparation method and application of a nano fluorescent probe for detecting HNO in a ratio mode. The nano fluorescent probe is prepared by wrapping a compound P-BODIPY-R by an amphoteric polymer; the structural general formula of the compound P-BODIPY-R is as follows: wherein R is 1 、R 2 The introduced substituent can adjust the electronic effect in the fluorescent probe molecule, so that the fluorescence changes in an exponential manner when the fluorescent probe responds to HNO. The nano fluorescent probe provided by the invention can be used for detecting active small molecule HNO in a living body in a ratio mode. According to the invention, the amphiphilic polymer is introduced and the fluorescent probe micromolecule P-BODIPY-R is wrapped to prepare the nano micelle, so that the biocompatibility of the probe micromolecule is greatly improved, and meanwhile, the nano fluorescent probe has good selectivity on HNO, stronger anti-interference capability and higher sensitivity, and can be used for carrying out real-time tracking detection on HNO in living cells and in zebra fish bodies. |
| priorityDate | 2018-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.