abstract |
The invention discloses a saponin derivative and its pharmaceutical composition and application. The structure of the saponin derivative is shown in formula (I), wherein X is C=O, C=N-OH, CH-OH, Y is C or CH, or X-Y is CH=CH; Z is CH2 or C=O; or R 2 and Y are connected through a covalent bond to form an ester. The saponin derivative retains strong antitumor activity, but its hemolytic toxicity is greatly reduced. |