| abstract |
The invention belongs to the technical field of organic synthetic drugs, and particularly relates to a substituted 1- (isoxazol-3-yl) -3- (3-fluoro-4-phenyl) urea derivative, and a preparation method and application thereof. The invention provides a substituted 1- (isoxazol-3-yl) -3- (3-fluoro-4-phenyl) urea derivative, the structural formula of which is shown in formula I. The invention also provides a preparation method of the substituted 1- (isoxazol-3-yl) -3- (3-fluoro-4-phenyl) urea derivative, and an application of the derivative in preparing FMS-like tyrosineUse of a kinase 3 inhibitor. Provides a new effective selection for the preparation of kinase inhibitors, autoimmune disease resistant drugs and angiogenesis inhibitors and antitumor drugs in the field, and has good application prospect. |