http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108341775-B

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-227
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-227
filingDate 2017-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2021-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108341775-B
titleOfInvention Synthetic method of rebamipide intermediate
abstract The invention discloses a key intermediate 2-amino-3- [2 (1) for synthesizing rebamipide H ) -quinolone-4]A novel process for the production of propionic acid. The method comprises the step of reacting aspartic acid with 2-hydroxyquinoline to prepare the rebamipide key intermediate 2-amino-3- [2 (1) H ) -quinolone-4]Propionic acid and p-chlorobenzoyl chloride are condensed to prepare rebamipide. The intermediate synthesis method has the advantages of cheap and easily-obtained raw materials, short reaction steps and good optical purity. 。
priorityDate 2017-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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