http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108314639-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-08 |
| filingDate | 2018-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108314639-B |
| titleOfInvention | Compound (E) -3-(1- methylpyrrolidin- 2- yl)-acrylic acid hydrochloride and synthetic method |
| abstract | The invention discloses compound (E) -3- (1- methylpyrrolidin- 2- yl)-acrylic acid hydrochloride and synthetic methods.Shown in the compound structure such as formula (I).Its synthetic method are as follows: with BOC-L- prolinol (or BOC-D- prolinol) for starting material; through being oxidized to aldehyde; take off BOC protective agent; it is reacted again with alkyl halide; synthesis (S is reacted through Wittig again; E) -3- (1- methylpyrrolidin- 2- yl)-ethyl acrylate; (S is obtained at salt after hydrolysis; E) -3- (1- methylpyrrolidin- 2- yl)-acrylic acid hydrochloride [or (R, E) -3- (1- methylpyrrolidin- 2- yl)-acrylic acid hydrochloride].The compound can prepare quinazoline or quinolines derivative as medicine intermediate. |
| priorityDate | 2018-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.