http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108299458-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433 |
| filingDate | 2017-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108299458-B |
| titleOfInvention | Oridonin derivative and preparation method and application thereof |
| abstract | The invention discloses an oridonin derivative and a preparation method and application thereof. The oridonin derivative has a structure shown in the following general formula I, II, III or IV: . The invention provides the oridonin derivative with higher antitumor activity, higher intercellular selectivity, lower dosage and lower toxicity by changing the hydroxyl groups at the 1, 6 and 14 positions or performing ring-changing transformation at the 6 and 7 positions on the premise of not damaging the active center of the oridonin. The direct killing effect of the compound on cancer cells of liver cancer, multiple myeloma and lung cancer of human body is 3-5 times higher than that of rubescensine A, and the activity of the compound is 11 times higher than that of the rubescensine A, so that the compound can be used for preparing anti-tumor drugsThe application of the medicine in treating liver cancer, multiple myeloma, lung cancer, etc. |
| priorityDate | 2017-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.