http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108299434-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2018-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108299434-B |
| titleOfInvention | Preparation method of tadalafil crystal form I |
| abstract | The invention provides a preparation method of a tadalafil crystal form I, which comprises the steps of dissolving a crude product of tadalafil and Sodium Dodecyl Sulfate (SDS) in acetonitrile water, and evaporating, cooling and crystallizing to obtain the tadalafil crystal form I. According to the invention, by introducing the sodium dodecyl sulfate, the dosage of the solvent is improved from the existing more than 50-80 times to 8-20 times, so that the dosage of the organic solvent is greatly reduced. The method has the advantages of simple operation, high yield, short production period and lower cost, and is more suitable for industrial production. |
| priorityDate | 2018-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.