http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108299430-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67aa3bc75203266389dcde6a7cb83250 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-06 |
| filingDate | 2017-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9759a76d15f20b046448c2e13be0eb5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9021415fb10aa7fe2113eedf2bfa35f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff14dfad7eb59aeadb20706bd42c2083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_601b06ba6a0b0b5e724d641300a49d7f |
| publicationDate | 2018-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108299430-A |
| titleOfInvention | Benzodiazepine alkaloids and their synthesis method and application |
| abstract | The invention discloses a benzodiazepine alkaloid compound and a pharmaceutically acceptable salt thereof. The structure of the compound is shown in the general formula (I): In formula (I), R 1 , R 2 and R 3 are independently hydrogen, C 1-4 alkyl or C 1-4 alkanoyl; one of R 4 and R 5 is a benzene ring or a substituted benzene ring, and the other One is hydrogen, a benzene ring or a substituted benzene ring, and the substituents on the substituted benzene ring are hydroxyl, cyano, amino, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkane Amino group, C 1~4 alkanoyl group or C 1~4 alkoxyacyl group. The synthesis method of the compound and the application in the preparation of antitumor drugs are also disclosed. The compound represented by the formula (I) of the present invention shows strong inhibitory activity on human lung cancer stem cells PC9-Nanog and human lung cancer stem cells PC9-Oct4, has significant anti-lung cancer activity, and can be used to prepare anti-tumor, especially anti-lung cancer drugs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112557354-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112557354-B |
| priorityDate | 2017-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.